Cleveland Clinic - Department of Neurosciences, Cleveland Clinic - Department of Neurosciences, State University of New York (SUNY) - University at Buffalo, Karolinska Institutet, Case Western Reserve University, Case Western Reserve University - Department of Genetics and Genome Sciences, Cleveland Clinic - Department of Neurosciences, Karolinska Institutet, University of Buffalo - Department of Pharmacology and Toxicology and Cleveland Clinic - Department of Neurosciences