Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Tohoku Medical and Pharmaceutical University, Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Asahikawa Medical University, Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science, Mayo Clinic - Florida and Asahikawa Medical University, Department of Medicine, Division of Metabolism and Biosystemic Science