Massachusetts General Hospital - Center for Genomic Medicine, Massachusetts General Hospital - Center for Genomic Medicine, Boston University - Department of Biostatistics, Massachusetts General Hospital - Center for Genomic Medicine, Massachusetts General Hospital - Center for Genomic Medicine, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, Massachusetts General Hospital - Center for Genomic Medicine, Massachusetts Institute of Technology and Harvard University - Programs in Metabolism and Medical & Population Genetics, Massachusetts General Hospital, Massachusetts General Hospital - Center for Genomic Medicine, University of Virginia, National Institute on Aging (NIA), Merck & Co., Inc., Harvard Medical School - Division of Endocrinology, Diabetes, and Metabolism, University of Copenhagen - The Novo Nordisk Foundation Center for Basic Metabolic Research, Brigham and Women's Hospital, Boston University - Department of Biostatistics, The University of Manchester - Manchester Academic Health Science Centre, Massachusetts General Hospital - Center for Genomic Medicine and Massachusetts General Hospital - Center for Genomic Medicine