Anne-Marie Turner

University of North Carolina (UNC) at Chapel Hill

102 Ridge Road

Chapel Hill, NC NC 27514

United States

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Scholarly Papers (1)

1.

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

Number of pages: 98 Posted: 01 Jul 2019
University of North Carolina (UNC) at Chapel Hill - Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina (UNC) at Chapel Hill, University of North Carolina (UNC) at Chapel Hill, University of North Carolina (UNC) at Chapel Hill - Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina (UNC) at Chapel Hill - Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina (UNC) at Chapel Hill - Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina (UNC) at Chapel Hill, University of North Carolina (UNC) at Chapel Hill - Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina (UNC) at Chapel Hill and University of North Carolina (UNC) at Chapel Hill - Center for Integrative Chemical Biology and Drug Discovery
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Abstract:

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Embryonic Ectoderm Development (EED), Enhancer of Zeste Homolog 2 (EZH2), Suppressor of Zeste Homolog 12 (SUZ12), Polycomb Repressive Complex 2 (PRC2), bivalent chemical degrader, von-Hippel Lindau (VHL), diffuse large B-cell lymphoma (DLBCL), histone methyltransferase (HMT)