Michael J. May

University of Pennsylvania - Department of Biomedical Sciences

United States

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Scholarly Papers (1)

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BCR-Induced Ca 2+ Signals Dynamically Tune Key Checkpoints that Control the Survival, Metabolic Reprogramming, and Proliferation of Naïve B Cells

Number of pages: 56 Posted: 28 Aug 2019
University of Pennsylvania - Department of Pathobiology, University of Pennsylvania - Department of Pathobiology, University of Pennsylvania - Department of Pathology and Lab Medicine, University of Pennsylvania - Department of Biomedical Sciences, University of Pennsylvania - Department of Pathology, Drexel University - School of Biomedical Engineering, University of Pennsylvania - Department of Pathobiology, University of Pennsylvania - Department of Pathology and Lab Medicine, University of Pennsylvania - Department of Biomedical Sciences, University of Pennsylvania - Department of Biomedical Sciences and University of Pennsylvania - Department of Pathobiology
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Abstract:

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B lymphocyte, BCR signal strength, CD40, Calcium, Orai, STIM, c-Myc, Bcl-xL, proliferation, apoptosis, metabolic reprogramming, mTORC1, Nuclear Factor Kappa Beta, c-Rel, p65, NFAT, Follicular B cell, survival, cell cycle, Calcineurin, Akt, Foxo1, phospho-S