Kathryn M. Monroe

Denali Therapeutics

United States

  • Denali Therapeutics

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TREM2 Regulates Microglial Cholesterol Metabolism Upon Chronic Phagocytic Challenge

Number of pages: 85 Posted: 03 Sep 2019
Alicia A. Nugent, Karin Lin, Bettina Van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S. Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C.G. Haddick, Melina Lenser, Timothy K. Earr, Ju Shi, Jason C. Dugas, Benjamin J. Andreone, Todd Logan, Hilda O. Solanoy, Hang Chen, Ankita Srivastava, Suresh B. Poda, Pascal E. Sanchez, Ryan J. Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W. Lewcock, Kathryn M. Monroe and Gilbert Di Paolo
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Abstract:

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microglia, Lipid metabolism, lipid dysregulation, cholesterol, cholesteryl ester, TREM2, ApoE, myelin, neurodegeneration, Alzheimer's disease, phagocytosis