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Dario R. Alessi

University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit

United Kingdom

SCHOLARLY PAPERS

4

DOWNLOADS

413

TOTAL CITATIONS

0

Scholarly Papers (4)

1.

A Pathogenic Variant in Rab32 Causes Autosomal Dominant Parkinson's Disease and Activates LRRK2 Kinase

Number of pages: 30 Posted: 10 Jan 2024
University College London, University of Florida, University of Lubeck, University of Alabama at Birmingham, University College London, University of Alabama at Birmingham - Department of Neurology, University College London, University of British Columbia (UBC) - Department of Medical Genetics, University of British Columbia (UBC) - Pacific Parkinson’s Research Centre, University of British Columbia (UBC) - Pacific Parkinson’s Research Centre, University of Saskatchewan, University of Saskatchewan, University of Saskatchewan, University College London, University of Tübingen - Institute of Medical Genetics and Applied Genomics, University of Tübingen, University of Angers - Research Unit U1127, Sorbonne University, Sorbonne University, University of British Columbia (UBC) - Department of Medical Genetics, University College London - Department of Molecular Neuroscience, University of Alabama at Birmingham - Department of Neurology, Duke University - Center for Neurodegeneration and Neurotherapeutics, University of Oxford, University College London - Department of Clinical and Movement Neurosciences, University of Tübingen - Institute for Clinical Epidemiology and Applied Biometrics,, McGill University - The Neuro (Montreal Neurological Institute-Hospital), Istanbul Medipol University - Department of Neurology, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, Queen Mary, University of London, National Institute of Neurology of Tunis, National Institute of Neurology of Tunis, National Institute of Neurology of Tunis, Independent, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit and University of Florida
Downloads 230 (331,797)

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RAB32, PINK1, LRRK2, Parkinson's disease

2.

Development of a Highly Potent and Selective Degrader of LRRK2

Number of pages: 7 Posted: 04 May 2023
Harvard University - Dana-Farber Cancer Institute, University of Dundee, Southern Technical University - Department of Medical Laboratory Techniques, Harvard University - Dana-Farber Cancer Institute, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit and Stanford University - Department of Chemical and Systems Biology
Downloads 90 (742,061)

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LRRK2, LRRK2 degrader, MLi-2, PROTAC

3.

Structural Basis for Rab8a GTPase Recruitment of RILPL2 via LRRK2-Mediated Phosphorylation of Switch 2

Number of pages: 41 Posted: 11 Sep 2019
Trinity College (Dublin) - School of Biochemistry and Immunology, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, Trinity College (Dublin) - School of Biochemistry and Immunology, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit and Trinity College (Dublin) - School of Biochemistry and Immunology
Downloads 50 (1,063,489)

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Rab8a GTPase, LRRK2 protein kinase, phosphorylation, membrane trafficking, Parkinson's disease, RILP-like protein 2, X-ray crystallography

4.

Structural Basis for Binding of RILPL1 to TMEM55B Reveals a Lysosomal Platform for Adaptor Assembly Through a Conserved TBM Motif

Number of pages: 46 Posted: 22 Aug 2025
Trinity College (Dublin) - School of Biochemistry and Immunology, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee - MRC Protein Phosphorylation and Ubiquitylation Unit, Trinity College (Dublin) - School of Biochemistry and Immunology and Independent
Downloads 43 (1,145,425)

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TMEM55B, RILPL1, phosphorylated Rab GTPases, LRRK2 kinase, membrane trafficking, cytosolic adaptor proteins, lysozome, X-ray crystallography