Kawasaki Medical School - Department of General Internal Medicine, Toho University - School of Medicine, Kumamoto University, National Cerebral and Cardiovascular Center Research Institute, National Institute for Environmental Studies - Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Japan, National Institute for Environmental Studies, Japan, Kyoto University, National Cerebral and Cardiovascular Centre - Department of Cardiovascular Medicine, National Center of Neurology and Psychiatry, Shizuoka General Hospital, Nihon University Hospital - Cardiovascular Disease Center, Toho University - School of Medicine, Kawaguchi Cardiovascular and Respiratory Hospital, Kyushu University - Faculty of Medical Sciences and Independent