Michael S. Bonkowski

Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research

United States

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DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

CELL-D-19-02606
Number of pages: 97 Posted: 08 Oct 2019
Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Zymo Research Corporation, Zymo Research Corporation, Zymo Research Corporation, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, National Institutes of Health - Experimental Gerontology Section, Tokyo Medical and Dental University - Department of Stem Cell Biology, Tokyo Medical and Dental University - Department of Stem Cell Biology, Vium Inc., Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Cancer Center, Harvard University - Medical School, Harvard Medical School - Cancer Center, Harvard University - Department of Stem Cell and Regenerative Biology, Keio University - Department of Ophthalmology, University of Nebraska Medical Center - Division of Geriatrics, Gerontology, and Palliative Medicine, Universidade de Coimbra - Department of Life Sciences, Harvard University - Medical School, Harvard University - Medical School, University of Washington - Department of Pathology, Brown University - Department of Molecular Biology, Cell Biology and Biochemistry, Brown University - Department of Molecular Biology, Cell Biology and Biochemistry, Harvard Medical School - Program in Dermatopathology, National Institutes of Health - Laboratory of Receptor Biology and Gene Expression, Harvard Medical School - Schepens Eye Research Institute, Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research and Harvard Medical School - Paul F. Glenn Center for Biology of Aging Research
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Abstract:

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DNA damage, chromatin, aging, epigenetic clock, histone modification, RCM(Relocalization of Chromatin Modifiers)