Massachusetts General Hospital - Center for Genomic Medicine, Boston University - Department of Biostatistics, Massachusetts General Hospital - Center for Genomic Medicine, Massachusetts General Hospital - Center for Genomic Medicine, Massachusetts Institute of Technology and Harvard University - Broad Institute, Broad Institute - The Metabolomics Program, Boston University - Section of Computational Biomedicine, University of Pennsylvania - Cardiovascular Institute, Boston University - Department of Biostatistics, Boston University - Preventive Medicine and Epidemiology, Beth Israel Deaconess Medical Center - Division of Cardiovascular Medicine, Massachusetts Institute of Technology and Harvard University - Broad Institute, University of Pennsylvania - Institute for Translational Medicine and Therapeutics and Harvard University - Center for Genomic Medicine