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Yiyi Ma

Massachusetts Institute of Technology and Harvard University - Broad Institute

415 Main Street

Cambridge, MA 02142

United States

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Scholarly Papers (1)

1.

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology

Number of pages: 64 Posted: 12 Nov 2019
Harvard University - Brigham and Women's Hospital, Massachusetts Institute of Technology and Harvard University - Broad Institute, Columbia University - Center for Translational & Computational Neuroimmunology, Rush University - Alzheimer’s Disease Center, Rush University - Alzheimer’s Disease Center, Massachusetts Institute of Technology and Harvard University - Broad Institute, Krembil Centre for Neuroinformatics - Centre for Addiction and Mental Health, University of British Columbia (UBC) - Department of Medical Genetics, Pacific Northwest National Laboratory, Massachusetts General Hospital - Department of Neurology, Mayo Clinic - Florida - Department of Neuroscience, Rush University - Alzheimer’s Disease Center, Rush University Medical Center - Rush Alzheimer’s Disease Center and Columbia University - Center for Translational and Systems Neuroimmunology
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Abstract:

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Expression quantitative trait loci (eQTL), Genetics, Gene expression, Gene regulation, transcription, Biochemical networks, gene co-expression networks, RNA, micro RNA, Functional genomics, Genome-wide association study (GWAS), Genetic interaction, Epistasis, neurodegeneration, Aging, Dementia, Cognition, Cognitive aging, Cognitive Resilience, Neuropathology, Amyloid-beta, Alzheimer's disease, TDP-43, Limbic-predominant age-related TDP-43 encephalopathy (LATE), APOE, TMEM106B, GRN, RBFOX1, RNA splicing, Synapse, Lysosome, Myelination