Zhejiang Provincial Key Laboratory of Orthopaedics - Department of Orthopaedics, Wenzhou Medical University, Jiangsu Cancer Hospital, University of Washington - Department of Radiation Oncology, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Istituto Tumori “Giovanni Paolo II”, Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Orthopaedic Implants, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - National Cancer Institute – Fondazione “G Pascale”, Zhejiang Provincial Key Laboratory of Orthopaedics - Department of Orthopaedics, University of Rochester - School of Medicine and Dentistry and Zhejiang Provincial Key Laboratory of Orthopaedics - Department of Orthopaedics