Andrea Ventura

Memorial Sloan Kettering Cancer Center - Cancer Biology and Genetics Program

United States

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TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors

CELL-D-19-03416
Number of pages: 51 Posted: 17 Dec 2019
Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center - Cancer Biology and Genetics Program, Agency for Science, Technology and Research (A*STAR) - Bioinformatics Institute, Memorial Sloan Kettering Cancer Center - Department of Medicine, Memorial Sloan Kettering Cancer Center - Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center - Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, University of Torino - Department of Oncology, FPO-IRCCS - Candiolo Cancer Institute, Memorial Sloan Kettering Cancer Center - Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program, H. Lee Moffitt Cancer Center and Research Institute - Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute - Department of Drug Discovery, University of Torino - Department of Oncology, Memorial Sloan Kettering Cancer Center - Department of Pathology, Memorial Sloan Kettering Cancer Center - Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center - Department of Medicine, Agency for Science, Technology and Research (A*STAR) - Bioinformatics Institute, Memorial Sloan Kettering Cancer Center - Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center - Department of Medicine and Memorial Sloan Kettering Cancer Center - Human Oncology and Pathogenesis Program
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Abstract:

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drug resistance, tyrosine kinase inhibitors, cancer, signaling