University of Zurich - Division of Immunology, University of Zurich - Children's Research Center, University of Oxford - Department of Statistics, University of Zurich - Division of Immunology, University of Zurich - Division of Immunology, University of Basel - Immunodeficiency Laboratory, University of Basel - Immunodeficiency Laboratory, University of Applied Sciences and Arts, Northwestern Switzerland - Institute of Medical Engineering and Medical Informatics, University of Oxford - Oxford Vaccine Group, University of Oxford - Department of Statistics and University of Zurich - Division of Immunology