University of Cambridge - University Division of Anaesthesia, Addenbrooke’s Hospital - Cambridge Institute for Medical Research, University of Cambridge - Department of Pharmacology, NHS Foundation Trust - MRC Metabolic Diseases Unit, University of Cambridge - University Division of Anaesthesia, University of Cambridge - Department of Pharmacology, University of Cambridge - Department of Pharmacology, Addenbrooke’s Hospital - Cambridge Institute for Medical Research, Addenbrooke’s Hospital - Cambridge Institute for Medical Research, University of Liverpool, University of Cambridge - University Division of Anaesthesia, University of Cambridge - University Division of Anaesthesia, Karolinska Institutet - Department of Medical Biochemistry and Biophysics, University of Cambridge - Division of Anaesthesiology, NHS Foundation Trust - Metabolic Research Laboratories, University of Cambridge - Department of Pharmacology and Addenbrooke’s Hospital - Cambridge Institute for Medical Research