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Annie M. Curtis

Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences

Dublin

Ireland

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Scholarly Papers (1)

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Arginase-2 is Essential for IL-10 Metabolic Reprogramming of Inflammatory Macrophages at the Mitochondria

Number of pages: 51 Posted: 20 Mar 2020
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Victoria G. Lyons, Mariana P. Cervantes-Silva, Nadine Assmann, Katja Dettmer, Glenn R. Bantug, Daniel J. Gough, Chiara De Santi, Fidinny I. Hamid, Frances Mc Nally, Conor Duffy, Aoife L. Gorman, Alex M. Liddicoat, Peter J. Oefner, David E. Levy, Ed C. Lavelle, David K. Finlay, Annie M. Curtis, Christoph Hess, Paul J. Hertzog, Bryan RG Williams, Natalie L. Payne and Claire McCoy
Royal College of Surgeons in Ireland (RCSI) - Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences, Hudson Institute of Medical Research, Hudson Institute of Medical Research, Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences, Trinity College (Dublin) - School of Medicine, University of Regensburg, University Hospital Basel - Immunobiology Laboratory, Hudson Institute of Medical Research, Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences, Hudson Institute of Medical Research, Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences, Trinity College (Dublin) - School of Medicine, Trinity College (Dublin) - School of Medicine, University of Regensburg, University of Regensburg, Trinity College (Dublin) - School of Medicine, Trinity College (Dublin) - School of Medicine, Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences, University Hospital Basel - Immunobiology Laboratory, Hudson Institute of Medical Research, Hudson Institute of Medical Research, Monash University and Royal College of Surgeons in Ireland (RCSI) - School of Pharmacy and Biomolecular Sciences
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Abstract:

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interleukin-10 (IL-10), Arginase-2 (Arg2), mitochondria, fusion, oxidative phosphorylation (OxPhos), succinate dehydrogenase (SDH), interleukin-1β (IL-1β), Macrophages, mammalian target of rapamycin (mTOR), extracellular signal regulated kinase 1/2 (ERK1/2).