National Cheng Kung University - Department of Mathematics, Chang Gung University - Department of Thoracic Medicine, Duke University, Trinity College of Arts & Sciences, Department of Staistical Science, National Chiao Tung University - Department of Applied Mathematics, Mackay Memorial Hospital - Division of Chest, Taipei Medical University - Sleep Center, Buddhist Tzu Chi Medical Foundation - Division of Pulmonary Medicine, Buddhist Tzu Chi Medical Foundation - Department of Pulmonary Medicine, National Yang Ming University - Department of Chest Medicine, Mackay Memorial Hospital - Division of Chest, Taipei Medical University - Sleep Center, Buddhist Tzu Chi Medical Foundation - Division of Pulmonary Medicine, Buddhist Tzu Chi Medical Foundation - Department of Pulmonary Medicine, National Yang Ming University - Center of Sleep Medicine and Chang Gung University - Department of Thoracic Medicine