David Chien Lye

Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine

National University of Singapore (NUS) - Department of Microbiology and Immunology

5 Science Drive 2 Blk MD4, Level 3

117545

Singapore

SCHOLARLY PAPERS

10

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5,987

SSRN CITATIONS

0

CROSSREF CITATIONS

1

Scholarly Papers (10)

1.

Clinical and Virological Features of SARS-CoV-2 Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.315 (Beta), and B.1.617.2 (Delta)

Number of pages: 24 Posted: 07 Jun 2021
National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, Ministry of Health, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, Agency for Science, Technology and Research (A*STAR) - Bioinformatics Institute, National Centre for Infectious Diseases, National University of Singapore (NUS) - Department of Microbiology and Immunology, Ministry of Health, Singapore, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine and National Centre for Infectious Diseases, Singapore
Downloads 5,613 (1,991)
Citation 25

Abstract:

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COVID-19; SARS-CoV-2; B.1.1.7; B.1.351; B.1.617; variants of concern; severity; mortality

2.

Antibody Response of Heterologous vs Homologous mRNA Vaccine Boosters Against the SARS-CoV-2 Omicron Variant: Interim Results from the PRIBIVAC Study, A Randomized Clinical Trial

Number of pages: 35 Posted: 16 Mar 2022
National Centre for Infectious Diseases, Duke NUS Medical School, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, University of Liverpool, University of Liverpool, Duke-NUS Medical School, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Duke-NUS Medical School, University of Liverpool, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National University of Singapore (NUS), National Centre for Infectious Diseases, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Duke-NUS Medical School - Programme in Emerging Infectious Diseases and National Centre for Infectious Diseases, Singapore
Downloads 193 (218,341)

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COVID-19 vaccine booster, humoral immunity, omicron, live virus neutralization

3.

Association of SARS-CoV-2 Clades with Clinical, Inflammatory and Virologic Outcomes: An Observational Study

Number of pages: 33 Posted: 05 Jan 2021
National Centre for Infectious Diseases, Singapore, National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), National Centre for Infectious Diseases, Singapore, Duke NUS Medical School, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Government of the Republic of Singapore - Communicable Diseases Division, Ministry of Health, Singapore, National Centre for Infectious Diseases, Singapore, Duke NUS Medical School, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Singapore General Hospital - Department of Infectious Diseases, Ng Teng Fong General Hospital - Division of Infectious Diseases, National University Health System, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Khoo Teck Puat Hospital, Changi General Hospital - Department of Infectious Diseases, Alexandra Hospital, Duke-NUS Medical School, National Centre for Infectious Diseases, National University of Singapore (NUS) - Department of Microbiology and Immunology, Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Duke NUS Medical School, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Bioinformatics Institute, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine and Ministry of Health, Singapore
Downloads 40 (572,445)

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4.

Comparison of the Clinical Features, Viral Shedding and Immune Response in Vaccine Breakthrough Infection by the Omicron and Delta Variants

Number of pages: 35 Posted: 24 Jun 2022
National University of Singapore (NUS) - National University Hospital, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National University of Singapore (NUS) - Department of Microbiology and Immunology, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National University of Singapore (NUS) - Department of Microbiology and Immunology, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Singapore, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National Centre for Infectious Diseases, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National University of Singapore (NUS) - Department of Microbiology and Immunology, National University of Singapore (NUS) - Department of Microbiology and Immunology, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National Centre for Infectious Diseases, Singapore and Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs
Downloads 33 (623,320)

Abstract:

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COVID-19, SARS-CoV-2, Delta, Omicron, variants of concern, vaccine breakthrough

5.

Real-World Effectiveness of Sotrovimab and Remdesivir for Early Treatment of High-Risk Hospitalized COVID-19 Patients

Number of pages: 20 Posted: 08 Jul 2022
National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, National Centre for Infectious Diseases, National University of Singapore (NUS) - Department of Microbiology and Immunology, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Singapore, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine and National Centre for Infectious Diseases
Downloads 27 (649,417)

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COVID-19, SARS-CoV-2, early-treatment, sotrovimab, remdesivir, high-risk

6.

Prolonged Inflammation in COVID-19 Survivors Resolves 2 Years After Coronavirus Disease 2019 (COVID-19)

Number of pages: 48 Posted: 27 Jun 2022
Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Independent, Independent, Changi General Hospital - Department of Infectious Diseases, National University of Singapore (NUS) - Department of Microbiology and Immunology, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, National Centre for Infectious Diseases, Singapore and Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs
Downloads 25 (663,640)

Abstract:

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Long COVID, inflammation, subclinical signs, COVID vaccine

7.

Immune Landscape of 382-Nt Deleted SARS-CoV-2 Reveals Heightened Adaptive Response Indicating Prophylactic Potential Against COVID-19

Number of pages: 90 Posted: 21 Oct 2020
Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore General Hospital - Department of Infectious Diseases, National University of Singapore (NUS) - Department of Microbiology and Immunology, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN) and Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN)
Downloads 22 (686,251)

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COVID-19, SARS-CoV-2, transcriptome, ORF8, deletion, RNA-seq

8.

SARS-CoV-2 Infection Generates Long-Lived Memory B Cells Against the Receptor Binding Domain of the Spike Protein

Number of pages: 41 Posted: 14 Dec 2021
Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), National University of Singapore (NUS) - Department of Microbiology and Immunology, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Changi General Hospital - Department of Infectious Diseases, National Centre for Infectious Diseases, Singapore, National University of Singapore (NUS) - Department of Microbiology and Immunology, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs and Agency for Science, Technology and Research (A*STAR) - A*STAR Infectious Diseases Labs
Downloads 15 (743,185)

Abstract:

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antibodies, memory B cells, SARS-COV-2, COVID-19, severity, RBD, spike protein, long-lived

9.

Sensitive Detection of Total Anti-Spike Antibodies and Isotype Switching in Asymptomatic and Symptomatic COVID-19 Patients

Number of pages: 44 Posted: 23 Oct 2020
Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, National Centre for Infectious Diseases, National Centre for Infectious Diseases, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), National Centre for Infectious Diseases, Singapore, National Centre for Infectious Diseases, Singapore General Hospital - Department of Infectious Diseases, Ng Teng Fong General Hospital - Division of Infectious Diseases, Changi General Hospital - Department of Infectious Diseases, Alexandra Hospital, National Centre for Infectious Diseases, National University of Singapore (NUS) - Department of Microbiology and Immunology, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Agency for Science, Technology and Research (A*STAR) - Singapore Immunology Network (SIgN), National Centre for Infectious Diseases and Agency for Science, Technology and Research (A*STAR) - Infectious Diseases Horizontal Technology Centre
Downloads 15 (743,185)

Abstract:

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SARS-CoV-2, COVID-19, serological, S protein, antibodies, IgG subclasses, symptomatic, asymptomatic

10.

Omicron Reactive Multi Protein Specific CD4 T Cells Defines Cellular Immune Response Induced by Inactivated Virus Vaccines

Number of pages: 50 Posted: 02 Jun 2022
National University of Singapore (NUS) - Program in Emerging Infectious Diseases, National University of Singapore (NUS) - Program in Emerging Infectious Diseases, National University of Singapore (NUS) - Program in Emerging Infectious Diseases, National University of Singapore (NUS) - Program in Emerging Infectious Diseases, National University of Singapore (NUS) - Program in Emerging Infectious Diseases, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, affiliation not provided to SSRN, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, National Centre for Infectious Diseases, Singapore, Nanyang Technological University (NTU) - Lee Kong Chian School of Medicine, Duke-NUS Medical School - Program in Emerging Infectious Diseases, Duke-NUS Medical School - Program in Emerging Infectious Diseases and Duke-NUS Medical School - Program in Emerging Infectious Diseases
Downloads 4 (851,551)

Abstract:

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COVID-19, inactivated vaccine, mRNA vaccine, T cell response, adaptive immune response