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Mark R. Gillrie

University of Calgary - Department of Medicine

3330 Hospital Drive NW

Calgary, Alberta T2N 4N1

Canada

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Release of Motor Neuron Exosomes Containing TDP-43 and mTNF-α Near the Neuromuscular Junction Induces Skeletal Muscle Atrophy and Reduced Contractility in a 3D Human Model of ALS

Number of pages: 57 Posted: 21 Apr 2020
Tatsuya Osaki, Zhengpeng Wan, Shunsuke Kitajima, David A. Barbie, Mark R. Gillrie and Roger D. Kamm
Massachusetts Institute of Technology (MIT) - Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT) - Department of Mechanical Engineering, Dana-Farber Cancer Institute - Department of Medical Oncology, Dana-Farber Cancer Institute - Department of Medical Oncology, University of Calgary - Department of Medicine and Massachusetts Institute of Technology (MIT) - Department of Mechanical Engineering
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Neuromuscular, Amyotrophic Lateral Sclerosis, muscle atrophy, exosome, TDP-43, organ-on-a-chip, microfluidic device