Shirley Chen

National Institutes of Health - Translational Stem Cell Biology Branch

Bethesda, MD

United States

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Macaque Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Therapeutic Approaches

Number of pages: 65 Posted: 29 Apr 2020
Tae-Hoon Shin, Shirley Chen, Stefan Cordes, Yifan Zhou, Aisha AlJanahi, So Gun Hong, Marcus A.F. Corat, Jean-Yves Metais, Manuel Buscarlet, Hannah Natanson, Kathy L. McGraw, Robert E. Donahue, Alan F. List, Lambert Busque, Kyung-Rok Yu and Cynthia Dunbar
National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, National Institutes of Health - Translational Stem Cell Biology Branch, University of Montreal, National Institutes of Health - Translational Stem Cell Biology Branch, H. Lee Moffitt Cancer Center and Research Institute, National Institutes of Health - Cellular and Molecular Therapeutics Branch, H. Lee Moffitt Cancer Center and Research Institute, University of Montreal, National Institutes of Health - Translational Stem Cell Biology Branch and National Institutes of Health - Translational Stem Cell Biology Branch
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Abstract:

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age-related clonal hematopoiesis, clonal hematopoiesis of indeterminate potential, hematopoietic stem and progenitor cells, clonal expansion, rhesus macaque, non-human primate model, CRISPR/Cas9, NLRP3 inflammasome, interleukin-6, tocilizumab