Chikashi Obuse

Osaka University - Laboratory of Genome Structure and Function

1-1 Yamadaoka

Suita

Osaka, 565-0871

Japan

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Scholarly Papers (1)

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RNaseH2A Downregulation Drives Chromosomal DNA Fragmentation and Accumulation of RNA-DNA Hybrids in Senescent Cells

CELL-REPORTS-D-20-01470
Number of pages: 66 Posted: 18 May 2020
Japanese Foundation for Cancer Research - Project for Cellular Senescence, Japanese Foundation for Cancer Research - Project for Cellular Senescence, Japanese Foundation for Cancer Research - Project for Cellular Senescence, Japanese Foundation for Cancer Research - Project for Cellular Senescence, National Institute of Advanced Industrial Science and Technology (AIST) - Health Research Institute, Kyushu University - 4Institute of Mathematics for Industry, Chiba University - Division of Diabetes, Metabolism and Endocrinology, Chiba University - Division of Diabetes, Metabolism and Endocrinology, Kanazawa University - Division of Genetics, Kanazawa University - Division of Genetics, Osaka University - Laboratory of Genome Structure and Function, Osaka University - Laboratory of Genome Structure and Function, Japanese Foundation for Cancer Research - Department of Gastroenterological Surgery, National Center for Global Health and Medicine - Department of Stem Cell Biology, Tokyo Medical and Dental University (TMDU) - Department of Molecular Genetics, University of Miami - Department of Medicine, Japan Science and Technology Agency (JST) - Precursory Research for Embryonic Science and Technology (PRESTO), Osaka University - Department of Molecular Microbiology and Japanese Foundation for Cancer Research
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Abstract:

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RNaseH2A, rNMPs, RNA-DNA hybrid, genomic DNA fragments, SASP, Werner syndrome, cancer