Kirsten Deprey

Tufts University - Department of Chemistry

Medford, MA 02155

United States

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Scholarly Papers (1)

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Protease Stability Correlates with Efficacy for High-Affinity, Cell Penetrant MDM2-Binding Stapled Peptides

Number of pages: 27 Posted: 26 May 2020
University of Michigan at Ann Arbor - Department of Chemical Engineering, University of Michigan at Ann Arbor - Department of Chemical Engineering, Harvard University - Dana-Farber Cancer Institute, University of Michigan at Ann Arbor - Department of Chemical Engineering, Tufts University - Department of Chemistry, University of Michigan at Ann Arbor - Department of Molecular, Cellular, and Developmental Biology, University of Michigan at Ann Arbor - Department of Chemical Engineering, University of Michigan at Ann Arbor - Department of Chemical Engineering, Tufts University - Department of Chemistry and University of Michigan at Ann Arbor - Department of Chemical Engineering
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Abstract:

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double-click stabilization, cytosolic penetration, protease stability, lipophilicity, alpha helixpeptides, p53 inhibition, cancer therapeutics