affiliation not provided to SSRN, affiliation not provided to SSRN, Swiss Group for Clinical Cancer Research (SAKK) Coordinating Center, Kantonsspital St Gallen, affiliation not provided to SSRN, University of Basel - University Hospital Basel, Cantonal Hospital Winterthur, University of Basel - University Hospital Basel, affiliation not provided to SSRN, Oncology Institute of Southern Switzerland, Oncology Institute of Southern Switzerland, affiliation not provided to SSRN, Kantonsspital Graubünden, Department of Oncology/Haematology, Cantonal Hospital Aarau, Lausanne University Hospital, affiliation not provided to SSRN, Varian Medical Systems, affiliation not provided to SSRN, Universitäres Lehrund Forschungsspital and affiliation not provided to SSRN