University of Palermo - Section of Gastroenterology and Hepatology, AstraZeneca Pharmaceuticals - Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Parma - Dipartimento di Economia, University of Gothenburg - Department of Molecular and Clinical Medicine, University of Eastern Finland - Department of Clinical Nutrition, AstraZeneca Pharmaceuticals - Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), AstraZeneca Pharmaceuticals - Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Florence - Department of Experimental and Clinical Medicine, University of Eastern Finland - Department of Medicine, affiliation not provided to SSRN, AstraZeneca Pharmaceuticals - IMED Biotech Unit, University of Palermo - Section of Gastroenterology and Hepatology, University of Palermo - Biomedical Department of Internal and Specialized Medicine (DI.BI.M.I.S.), Magna Graecia University of Catanzaro - Department of Experimental and Clinical Medicine, University of Palermo - Section of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - General Medicine and Metabolic Diseases, University of Milan - Department of Pathophysiology and Transplantation, University of Gothenburg - Department of Molecular and Clinical Medicine and University of Palermo - Section of Gastroenterology and Hepatology