Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Department of Diphtheria,Tetanus and Pertussis vaccine and Toxins, National Institute for Food and Drug Control, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, nstitute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Department of Diphtheria,Tetanus and Pertussis vaccine and Toxins, National Institute for Food and Drug Control, Department of Diphtheria,Tetanus and Pertussis vaccine and Toxins, National Institute for Food and Drug Control, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Department of Diphtheria,Tetanus and Pertussis vaccine and Toxins, National Institute for Food and Drug Control, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Disease, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) - Institute of Medical Biology and Chinese Academy of Sciences (CAS) - Institute of Medical Biology