State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Foresea Life Insurance Guangzhou General Hospital, Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Clinical College of Ophthalmology, Tianjin Medical University,Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmologyand Visual Science, Tianjin Eye Institute, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Department of Medical Research, Liuhuaqiao Hospital, Sun Yat-sen University (SYSU) - State Key Laboratory of Ophthalmology and Chinese Academy of Medical Sciences - Peking Union Medical College