Guangdong Academy of Medical Sciences - Department of General Surgery, Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Department of General Surgery, Guangdong Provincial People'sHospital,Guangdong Academy of Medical Sciences, Experimental Research Center, Dermatology Hospitalof Southern Medical University, Guangdong Provincial Dermatology Hospital, Sun Yat-Sen University - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research Center and Southern Medical University - Experimental Research Center