Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS - Laboratory of Methodology of Systematic Reviews and Guidelines Production, Grande Ospedale Metropolitano Niguarda - Department of Thoracic Oncology, University of Parma - Medical Oncology Unit, Università Vita-Salute San Raffaele - Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori - Department of Oncology, University of Parma - Medical Oncology Unit, Azienda Ospedaliero Universitaria di Modena - Department of Oncology, Azienda Ospedaliero-Universitaria Careggi, Università Vita-Salute San Raffaele - Department of Medical Oncology, University of Insubria, Istituto di Ricerche Farmacologiche Mario Negri IRCCS - Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS - Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS - Department of Oncology, Sapienza University of Rome - Department of Maternal, Infantile, and Urological Sciences and Fondazione IRCCS Istituto Nazionale dei Tumori - Department of Oncology