The Christie NHS Foundation Trust, The University of Manchester, University of Manchester - Digital Experimental Cancer Medicine, affiliation not provided to SSRN, The University of Manchester, The University of Manchester, The University of Manchester, affiliation not provided to SSRN, ITG, Inc. - ITG London, affiliation not provided to SSRN, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, University of Dundee, affiliation not provided to SSRN, affiliation not provided to SSRN, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, Hospital General Universitario Gregorio Marañón, affiliation not provided to SSRN, University of Southampton - University Hospital Southampton NHS Foundation Trust, Fundeni Clinical Institute, Lahey Hospital and Medical Center - Division of Cardiovascular Medicine, affiliation not provided to SSRN, University Hospitals Plymouth NHS Trust, University of Manchester - Digital Experimental Cancer Medicine, University of Manchester - Digital Experimental Cancer Medicine, Lahey Hospital and Medical Center - Division of Cardiovascular Medicine, affiliation not provided to SSRN, The Christie NHS Foundation Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, NHS Foundation Trust - Royal Marsden Hospital, Ninewells Hospital and Medical School, affiliation not provided to SSRN, University of Manchester - Research IT, affiliation not provided to SSRN, affiliation not provided to SSRN, University College London Hospital, Government of the United Kingdom - Oncology Department, Clatterbridge Cancer Centre, University College London - UCL Cancer Institute, Sheffield Teaching Hospitals NHS Foundation Trust, University of Southampton - Cancer Sciences Academic Unit, University of Lausanne - Lausanne University Hospital, Lahey Hospital and Medical Center, affiliation not provided to SSRN, Lahey Hospital and Medical Center - Department of Internal Medicine, affiliation not provided to SSRN, Centre Hospitalier Universitaire Vaudois (CHUV), Lahey Hospital and Medical Center, Bristol Haematology and Oncology Centre, affiliation not provided to SSRN, PSL Research University - Institut Curie, Royal Cornwall Hospital - Sunrise Centre, I.M. Sechenov First Moscow State Medical University, affiliation not provided to SSRN, affiliation not provided to SSRN, National Institute for Health Research (NIHR), Government of the United Kingdom - Oncology Department, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Hospital Universitario La Paz - Department of Medical Oncology, The Christie NHS Foundation Trust, Government of the United Kingdom - Weston Park Cancer Centre, Government of the United Kingdom - Weston Park Cancer Centre, affiliation not provided to SSRN, affiliation not provided to SSRN, The Christie NHS Foundation Trust, Independent, The University of Manchester, The University of Manchester and The Christie NHS Foundation Trust

University of Liverpool - National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in 31 Emerging and Zoonotic Infections, National Institute for Health Research (NIHR), National Institute for Health Research (NIHR), University of St. Andrews - Division of Infection and Global Health, HIV i-Base, Mortimer Market Centre, Central and North West London NHS Foundation Trust, Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, University of Edinburgh - Centre for Medical Informatics, University of Edinburgh - Centre for Medical Informatics, University of Liverpool - NIHR Health Protection Research Unit for Emerging and Zoonotic Infection, Imperial College London - National Heart and Lung Institute (NHLI), University of Edinburgh - Roslin Institute, National Institute for Health Research (NIHR) - Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections, University of Liverpool - Health Protection Research Unit in Emerging and Zoonotic Infections and Independent