Vienna University of Economics and Business Administration - Department of Statistics and Mathematics, Dana-Farber/Harvard Cancer Center, Brigham and Women's Hopsital/Harvard Medical School - Channing Laboratory, University of Wisconsin - Madison - Department of Statistics, University of California, Berkeley - Division of Biostatistics, ETH Zurich - Seminar for Statistics, affiliation not provided to SSRN, Harvard University - Department of Statistics, Technical University of Denmark - Centre for Biological Sequence Analysis, Mt. Sinai School of Medicine - Biomathematical Sciences, Dana-Farber/Harvard Cancer Center, University of Erlangen-Nürnberg, DKFZ (German Cancer Research Center), University of Milan - Department of Economics, Business and Statistics, Johns Hopkins University - Bloomberg School of Public Health, Vienna University of Technology, Dana-Farber Cancer Institute, ETH Zentrum - Seminar für Statistik, University of Washington - Department of Medical Education and Biomedical Informatics, Heidelberg University - StatLab Heidelberg, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Iowa - Department of Statistics & Actuarial Science, The University of Sydney - School of Mathematics and Statistics and affiliation not provided to SSRN