National Institute for Health Research (NIHR), School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University of Southampton - School of Clinical and Experimental Sciences, University Hospital Southampton NHS Foundation Trust - Department of Infection, University Hospital Southampton NHS Foundation Trust - Department of Infection, University Hospital Southampton NHS Foundation Trust - Department of Infection, University Hospital Southampton NHS Foundation Trust - Department of Infection, University Hospital Southampton NHS Foundation Trust - NIHR Southampton Biomedical Research Centre, Department of Microbiology, Hampshire Hospital NHS Foundation Trust, Basingstoke and North Hants Hospital, University of Amsterdam - Department of Medical Microbiology, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Clinical Research Facility,University Hospital Southampton NHS Foundation Trust, Universitè de Paris, Assistance Publique – Hôpitaux de Paris, Laboratoire de Virologie, Hôpital Bichat and University of Southampton - Southampton Clinical Trials Unit