Heidelberg University - Department of Pediatrics I, Heidelberg University - Department of Infectious Diseases, University of Freiburg - Center for Pediatrics and Adolescent Medicine, University of Tuebingen - Children's Hospital, affiliation not provided to SSRN, University of Freiburg - Faculty of Medicine, Heidelberg University - Dietmar-Hopp Metabolic Center, affiliation not provided to SSRN, Heidelberg University - Division of Child Neurology and Metabolic Disorders, affiliation not provided to SSRN, affiliation not provided to SSRN, Heidelberg University - Department of Pediatrics I, affiliation not provided to SSRN, Ulm University - Department of Pediatrics and Adolescent Medicine, Ulm University - Department of Pediatrics and Adolescent Medicine, affiliation not provided to SSRN, Ulm University - Institute of Virology, University of Tuebingen - Institute for Medical Virology and Epidemiology of Viral Diseases, University of Tuebingen - Institute for Medical Virology and Epidemiology of Viral Diseases, affiliation not provided to SSRN, German Center for Infection Research (DZIF), affiliation not provided to SSRN, affiliation not provided to SSRN, Heidelberg University - Department of Infectious Diseases, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Freiburg - Institute of Virology, affiliation not provided to SSRN, University of Freiburg - Faculty of Medicine, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Freiburg - Faculty of Medicine, University of Freiburg - Institute of Virology, University Children's Hospital Tübingen - General Paediatrics, Oncology/Haematology, affiliation not provided to SSRN, University of Tuebingen - Center for Pediatric Clinical Studies, University of Freiburg - Division of Infectious Diseases, Heidelberg University - Division of Child Neurology and Metabolic Disorders, Center for Doctoral Studies in Business, Graduate School of Economic & Social Sciences, University of Mannheim, University of Freiburg - Center for Pediatrics and Adolescent Medicine, Ulm University - Department of Pediatrics and Adolescent Medicine and Heidelberg University - Department of Infectious Diseases

Heidelberg University - Division of Child Neurology and Metabolic Disorders, Sant Joan de Déu Research Institute - Inborn Errors of Metabolism Unit, University of Vic-Central University of Catalonia - Faculty of Science and Technology, Bioinformatics and Medical Statistics Group, University of Hamburg - Children's Hospital, Aristotle University of Thessaloniki - 1st Department of Pediatrics, University of British Columbia (UBC) - Division of Biochemical Genetics, Charles University in Prague - Department of Pediatrics and Inherited Metabolic Disorders, Washington University in St. Louis - Department of Neurology, University of Nantes - Department of Neurometabolism and Metabolic Disorders, University of BarcelonaSant Joan de Déu Research Institute - Inborn Errors of Metabolism Unit, Hospital Clínico Universitario Virgen de la Arrixaca - Department of Pediatric Neurology, Miguel Servet University Hospital - Metabolic Diseases Unit, Charles University in Prague - Department of Pediatrics and Inherited Metabolic Disorders, University of Hamburg - Children's Hospital, Heidelberg University - Division of Child Neurology and Metabolic Disorders, Heidelberg University - Dietmar-Hopp Metabolic Center, Heidelberg University - Division of Child Neurology and Metabolic Disorders, Heidelberg University - Division of Child Neurology and Metabolic Disorders and Sant Joan de Déu Research Institute - Inborn Errors of Metabolism Unit