Fudan University - State Key Laboratory of Genetic Engineering, Institute of translational medicine, Shanghai University, Department of Orthopaedics, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Orthopedic Department, Taizhou Hospital Affiliated to Wenzhou Medical University, Zhejiang University - Department of Orthopaedics, Department of Orthopedics, Second Affiliated Hospital of Shantou University Medical College, Shanghai Jiao Tong University (SJTU) - Shanghai Key Laboratory of Orthopaedic Implants, Institute of translational medicine, Shanghai University, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Harvard University - Department of Nutrition, Fudan University - State Key Laboratory of Genetic Engineering and Shanghai University - Institute of Translational Medicine