affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Toronto - Princess Margaret Cancer Centre, affiliation not provided to SSRN, University of Toronto, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Western University, University of Toronto - Sunnybrook Health Sciences Centre, The Kinghorn Cancer Centre, affiliation not provided to SSRN, NHS Foundation Trust - Norfolk and Norwich University Hospital, The University of Sydney, University of Toronto, University of Ottawa, University of Toronto - Sunnybrook Health Sciences Centre, affiliation not provided to SSRN, University of Toronto, affiliation not provided to SSRN and University of Toronto - Sunnybrook Health Sciences Centre