McMaster University - Department of Medicine, McMaster University - Department of Medicine, National Health Service (NHS), St. Thomas Hospital, Thrombosis & Haemophilia Centre, Fondazione Policlinico Universitario A. Gemelli IRCCS - Department of Anesthesia and Intensive Care Medicine, University of Amsterdam - Department of Anesthesiology, University of Amsterdam - Department of Anesthesiology, University of Amsterdam - Department of Intensive Care, Independent and Independent