Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People’s Hospital affiliated to Tongji University School of Medicine, Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Tongji University - School of Medicine, Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People’s Hospital affiliated to Tongji University School of Medicine, Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Tongji University - Center for Translational Neurodegeneration and Regenerative Therapy and Tongji University - Center for Translational Neurodegeneration and Regenerative Therapy