John G. Doench

Broad Institute

415 Main Street

Cambridge, MA 02142

United States

SCHOLARLY PAPERS

2

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88

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Scholarly Papers (2)

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1.

High-Throughput CRISPR Screens to Dissect Macrophage- Shigella Interactions

Number of pages: 61 Posted: 07 Dec 2020
Yong Lai, Liang Cui, Gregory H. Babunovic, Sarah M. Fortune, John G. Doench and Timothy K. Lu
Singapore-MIT Alliance for Research and Technology - Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology - Antimicrobial Resistance Interdisciplinary Research Group, Harvard T.H. Chan School of Public Health - Department of Immunology and Infectious Diseases, Harvard University - Ragon Institute of MGH, MIT and Harvard, Broad Institute and Singapore-MIT Alliance for Research and Technology - Antimicrobial Resistance Interdisciplinary Research Group
Downloads 66 (709,303)

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Host-pathogen interactions, shigellosis, host-directed therapy, CRISPR-Cas9 knockout screen, CRISPRi screen, macrophage, TLR1/2 signaling, pyruvate catabolism

2.

Title: (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Tumorigenesis in IDH-Mutant Cancers

Number of pages: 65 Posted: 22 Dec 2021
Kathryn Gunn, Matti Myllykoski, John Z. Cao, Bofu Huang, Betty Rouaisnel, Bill H. Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Sam McBrayer, Hai Yan, Lucy A. Godley, Peppi Koivunen and Julie-Aurore Losman
Harvard University - Dana-Farber Cancer Institute, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, affiliation not provided to SSRN, Duke University, affiliation not provided to SSRN, University of Utah, Broad Institute, Harvard University - Dana-Farber Cancer Institute, University of California, Los Angeles (UCLA) - Department of Psychiatry and Biobehavioral Sciences, affiliation not provided to SSRN, Duke University, affiliation not provided to SSRN, University of Oulu - Biocenter Oulu and Harvard University - Dana-Farber Cancer Institute
Downloads 22 (1,079,405)

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Positive-selection CRISPR-Cas9 screen, mutant IDH, (R)-2HG, H3K4, histone methylation, oncogenic transformation, epigenetics, cancer metabolism, AML, glioma Introduction: