"Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, Sapienza University of Rome - Department of Radiological Sciences, Oncology and Pathology, "Sapienza" University of Rome - Department of Cardiovascular and Respiratory Diseases, Sapienza University of Rome - Department of Translational and Precision Medicine, University Campus Bio-Medico - Unit of Endocrinology and Diabetes, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Cardiovascular and Respiratory Diseases, Fatebenefratelli Hospital - Medical Statistics and Information Technology, Sapienza University of Rome - Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome - Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome - Department of Radiological Sciences, Oncology and Pathology, University Campus Bio-Medico - Unit of Endocrinology and Diabetes, Independent, "Sapienza" University of Rome - Department of Experimental Medicine, "Sapienza" University of Rome - Department of Experimental Medicine and Sapienza University of Rome - Department of Experimental Medicine

San Salvatore Hospital, AORN dei Colli - Monaldi Hospital, affiliation not provided to SSRN, Università Vita-Salute San Raffaele - San Raffaele Hospital, University Hospital “Ospedali Riuniti” - Cardiology And Arrhythmology Clinic, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Padua, "Sapienza" University of Rome - Department of Cardiovascular and Respiratory Diseases, University of Milan, affiliation not provided to SSRN, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - Ospedale Policlinico San Martino, Fondazione IRCCS Policlinico San matteo, affiliation not provided to SSRN, affiliation not provided to SSRN, University of Brescia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Johnson & Johnson, Johnson & Johnson and Johnson & Johnson

affiliation not provided to SSRN, Northern General Hospital, "Sapienza" University of Rome - Department of Cardiovascular and Respiratory Diseases, affiliation not provided to SSRN and affiliation not provided to SSRN