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Thomas J. Scriba

University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative

Private Bag X3

Rondebosch, 7701

South Africa

  • University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative

SCHOLARLY PAPERS

9

DOWNLOADS

909

TOTAL CITATIONS

2

Scholarly Papers (9)

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1.

Diagnostic Performance of Host Blood Transcriptomic Signatures for Pulmonary Tuberculosis in a Multi-Cohort Study of Symptomatic Patients in Africa

Number of pages: 26 Posted: 30 Nov 2023
Vanessa Muwanga, Simon C. Mendelsohn, Vinzeigh Leukes, Kim Stanley, Stanley Kimbung Mbandi, Mzwandile Erasmus, Marika Flinn, Tarryn-Lee Fisher, Rodney Raphela, Nicole Bilek, Stephanus T. Malherbe, Gerard Tromp, Gian Van der Spuy, Gerhard Walzl, Novel N. Chegou and Thomas J. Scriba
University of Cape Town (UCT), University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University, Stellenbosch University, University of Cape Town (UCT), Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Stellenbosch University, Stellenbosch University, University of Cape Town (UCT), University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University, Stellenbosch University, Stellenbosch University, Stellenbosch University - Division of Molecular Biology and Human Genetics, Stellenbosch University - Division of Molecular Biology and Human Genetics and University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative
Downloads 126 (576,708)
Citation 1

Abstract:

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Mycobacterium tuberculosis, blood, transcriptomic, mRNA, biomarker, performance, Africa, multi-cohort, Point-of-care, Triage, Non-sputum

2.

Live-Attenuated M. Tuberculosis Vaccine, MTBVAC, in Adults with or Without M. Tuberculosis Sensitization: A Phase 1b/2a Randomized, Controlled, Double-Blind, Dose-Escalation Trial

Number of pages: 29 Posted: 02 Oct 2023
Angelique Kany Kany Luabeya, Virginie Rozot, Claire Imbratta, Frances Ratangee, Justin Shenje, Michèle Tameris, Simon C. Mendelsohn, Hennie Geldenhuys, Michelle Fisher, Munyaradzi Musvosvi, Humphrey Mulenga, Nicole Bilek, Simbarashe Mabwe, Ingrid Murillo Jelsbak, Esteban Rodríguez, Eugenia Puentes, Juana Doce, Nacho Aguilo, Carlos Martin, Cadwill Pillay, Dereck Tait, Lewis Schrager, Marisa Russell, Kathryn Rutkowski, Devin Hunt, Thomas J. Scriba and Mark Hatherill
University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Biofabri, Biofabri, Biofabri, Biofabri, University of Zaragoza, University of Zaragoza, International AIDS Vaccine Initiative, International AIDS Vaccine Initiative, International AIDS Vaccine Initiative, International AIDS Vaccine Initiative, International AIDS Vaccine Initiative, International AIDS Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative
Downloads 124 (580,653)

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tuberculosis, MTBVAC, Vaccine, safety, immunogenicity

3.

Subclinical Tuberculosis in Children with Household Exposure to Mycobacterium Tuberculosis: A Prospective Cohort Study

Number of pages: 16 Posted: 26 Sep 2024
Humphrey Mulenga, Justin Shenje, Simon C. Mendelsohn, Angelique K.K. Luabeya, Michèle Tameris, Elisa Nemes, Nicolette Tredooux, Nicole Bilek, Elisabeth Beyers, Dejana Ivacik-Goncalves, Jason Andrews, Thomas R. Hawn, Karen Dobos, John Altin, Munyaradzi Musvosvi, Thomas J. Scriba and Mark Hatherill
University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stanford University - Division of Infectious Diseases and Geographic Medicine, University of Washington - Department of Global Health, Colorado State University, Fort Collins - Arthropod-Borne and Infectious Diseases Laboratory, The Translational Genomics Research Institute (TGen), University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative
Downloads 121 (604,538)

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Tuberculosis, TB, subclinical, child, household

4.

Performance of Two Fingerstick Blood Tests to Triage Adults with Symptoms of Pulmonary TB: A Prospective Multisite Diagnostic Accuracy Study

Number of pages: 23 Posted: 14 Nov 2024
Jayne S. Sutherland, Gian Van der Spuy, Jane Alexandra Shaw, Tracy Richardson, Elisa M. Tjon Kon Fat, Awa Gindeh, Olumuyiwa Owolabi, Nguyen Thuy Thuong Thuong, Le Hong Van, Nguyen Hoang Van, Dang Thi Thanh Thao, Harriet Mayanja-Kizza, Mary Nsereko, AnnRitah Namuganga, Sophie Nalukwago, John Belisle, Emmanuel Moreau, Adam Penn-Nicholson, Guy Thwaites, Jill Winter, Hazel M. Dockrell, Thomas J. Scriba, Kim Stanley, Bronwyn Smith, Novel N. Chegou, Stephanus T. Malherbe, Annemieke Geluk, Paul Corstjens, Gerhard Walzl and TrENDx-TB Consortium
London School of Hygiene & Tropical Medicine - Medical Research Council Unit: The Gambia, Stellenbosch University, Stellenbosch University, Stellenbosch University, Leiden University - Leiden University Medical Center (LUMC), London School of Hygiene & Tropical Medicine, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, Hospital of Tropical Diseases - Oxford University Clinical Research Unit, Hospital of Tropical Diseases - Oxford University Clinical Research Unit, University of Oxford, University of Oxford, Makerere University, Makerere University - Department of Medicine, Makerere University, Makerere University, Colorado State University, Fort Collins, the global alliance for diagnostics - FIND, Foundation for Innovative New Diagnostics (FIND), Hospital of Tropical Diseases - Oxford University Clinical Research Unit, Catalysis Foundation, London School of Hygiene & Tropical Medicine, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University, Stellenbosch University, Stellenbosch University - Division of Molecular Biology and Human Genetics, Stellenbosch University, Leiden University - Leiden University Medical Center (LUMC), Leiden University - Leiden University Medical Center (LUMC), Stellenbosch University - Division of Molecular Biology and Human Genetics and Independent
Downloads 120 (604,538)
Citation 1

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Biomarkers, Tuberculosis, Triage, Point-Of-Care, Diagnosis

5.

Safety, Reactogenicity, and Immunogenicity of Mtbvac in Infants: A Phase 2a Randomized, Double-Blind, Dose-Defining Trial in a Tb Endemic Setting

Number of pages: 22 Posted: 31 May 2024
Michèle Tameris, Virginie Rozot, Claire Imbratta, Hennie Geldenhuys, Simon C. Mendelsohn, Angelique Kany Kany Luabeya, Justin Shenje, Nicolette Tredooux, Michelle Fisher, Humphrey Mulenga, Nicole Bilek, Carly Young, Ashley Veldsman, Natasja Botes, Jelle Thole, Bernard Fritzell, Rajat Mukherjee, Ingrid Murillo Jelsbak, Esteban Rodrigues, Eugenia Puentes, Juana Doce, Dessislava Marinova, Jesus Gonzalo-Asensio, Nacho Aguilo, Carlos Martin, Thomas J. Scriba and Mark Hatherill
University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Biofabri, Biofabri, Mukherjee Consultants, Biofabri, Biofabri, Biofabri, Biofabri, University of Zaragoza, University of Zaragoza, University of Zaragoza, University of Zaragoza, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative
Downloads 117 (613,149)

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tuberculosis, newborns, vaccine, BCG, MTBVAC

6.

Newborn BCG Vaccination Induces Robust Infant IFN𝜸-Expressing NK Cell Responses to Mycobacteria

Number of pages: 47 Posted: 09 Sep 2021
Melissa Murphy, Melissa Murphy, Sara Suliman, Sara Suliman, Libby Briel, Helen Veldtsman, Nondumiso Khomba, Hadn Africa, Marcia Steyn, Candice I. Snyders, Ilana C. van Rensburg, Gerhard Walzl, Novel N. Chegou, Mark Hatherill, Willem Hanekom, Thomas J. Scriba and Elisa Nemes
University of Cape Town (UCT)University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Brigham and Women’s Hospital and Harvard Medical School - Division of Rheumatology, Inflammation, and ImmunityUniversity of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, affiliation not provided to SSRN, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University - Division of Molecular Biology and Human Genetics, Stellenbosch University - Division of Molecular Biology and Human Genetics, Stellenbosch University - Division of Molecular Biology and Human Genetics, Stellenbosch University - Division of Molecular Biology and Human Genetics, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative
Downloads 112 (630,858)

Abstract:

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NK cells, Myeloid cells, BCG, vaccination, infant, tuberculosis

7.

Prospective Validation of a Host Blood Transcriptomic Biomarker for Pulmonary Tuberculosis in People Living with HIV: A Diagnostic and Prognostic Accuracy Study

Number of pages: 54 Posted: 25 Jan 2021
Simon C. Mendelsohn, Andrew Fiore-Gartland, Adam Penn-Nicholson, Humphrey Mulenga, Stanley Kimbung Mbandi, Bhavesh Borate, Katie Hadley, Chris Hikuam, Munyaradzi Musvosvi, Nicole Bilek, Mzwandile Erasmus, Lungisa Jaxa, Rodney Raphela, Onke Nombida, Masooda Kaskar, Tom Sumner, Richard G. White, Craig Innes, William Brumskine, Andriëtte Hiemstra, Stephanus T. Malherbe, Razia Hassan-Moosa, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill and CORTIS-HR Study Team
University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Fred Hutchinson Cancer Research Center - Vaccine and Infectious Disease Division, Foundation for Innovative New Diagnostics (FIND), University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Fred Hutchinson Cancer Research Center, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, London School of Hygiene & Tropical Medicine, London School of Hygiene & Tropical Medicine, The Aurum Institute, Aurum Institute for Health Research, Stellenbosch University, Stellenbosch University, Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University - Division of Molecular Biology and Human Genetics, University of KwaZulu-Natal - Centre for the AIDS Programme of Research in South Africa (CAPRISA)University of the Witwatersrand - South African Medical Research Council, Aurum Institute, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and Independent
Downloads 87 (765,566)

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8.

Clinical Predictors of Pulmonary Tuberculosis Among South African Adults With HIV

Number of pages: 25 Posted: 19 Nov 2021
Simon C. Mendelsohn, Andrew Fiore-Gartland, Denis Awany, Humphrey Mulenga, Stanley Kimbung Mbandi, Michèle Tameris, Gerhard Walzl, Kogieleum Naidoo, Kogieleum Naidoo, Gavin Churchyard, Thomas J. Scriba, Mark Hatherill and CORTIS-HR Study Team
University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Fred Hutchinson Cancer Research Center - Vaccine and Infectious Disease Division, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Stellenbosch University - Division of Molecular Biology and Human Genetics, University of KwaZulu-Natal - Centre for the AIDS Programme of Research in South Africa (CAPRISA)University of the Witwatersrand - South African Medical Research Council, Aurum Institute, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and Independent
Downloads 62 (951,658)

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tuberculosis, Mycobacterium tuberculosis, HIV, clinical, model, prediction, risk, diagnosis, subclinical, case-finding

9.

Association of Treatment Adherence with Blood Transcriptomic Biomarker Trajectories during Tuberculosis Therapy: A Nested Multicentre Cohort Study

Number of pages: 20 Posted: 09 Jun 2026
Isabella B. B. Ferreira, Rodrigo C. Menezes, Simon C. Mendelsohn, Mariana Araújo-Pereira, Valeria C. Rolla, Fernanda C. Q. Mello, Marcelo Cordeiro-Santos, Timothy R. Sterling, Thomas J. Scriba and Bruno B. Andrade
Bahiana School of Medicine and Public Health, Instituto de Pesquisa Clínica e Translacional, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative, Oswaldo Cruz Foundation (FIOCRUZ), - Evandro Chagas National Institute of Infectious Diseases (INI), Universidade Federal do Rio de Janeiro (UFRJ), Universidade do Estado do Amazonas - Programa de Pós-Graduação em Medicina Tropical, Vanderbilt University - Division of Infectious Diseases, University of Cape Town (UCT) - South African Tuberculosis Vaccine Initiative and Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative
Downloads 40

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Tuberculosis, Adherence, Treatment, RNA, Host, Blood, Prognostic, Transcriptomic, Biomarkers