University of Washington - Department of Physics, The University of Hong Kong - HKU-Pasteur Research Pole, Max Planck Institute for Dynamics and Self-Organization, University of Washington - Department of Genome Sciences, Max Planck Institute for Dynamics and Self-Organization, The University of Hong Kong - HKU-Pasteur Research Pole, The University of Hong Kong - HKU-Pasteur Research Pole, Princess Margaret Hospital - Department of Medicine, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, The Scripps Research Institute - Department of Integrative Structural and Computational Biology, The Scripps Research Institute - Department of Integrative Structural and Computational Biology, The University of Hong Kong - School of Public Health, University of Illinois at Urbana-Champaign - Department of Biochemistry, University of Washington - Department of Physics and The University of Hong Kong - HKU-Pasteur Research Pole