Cardiff University - Division of Infection and Immunity, Respiratory Health Implementation Group, Institute for Clinical Science and Technology, Cardiff University - Department of Population Health, Cardiff University - Division of Infection and Immunity, Respiratory Health Implementation Group and Aneurin Bevan University Health Board - Department of Respiratory Medicine, Swansea University - College of Human and Health Sciences, Betsi Cadwaladr University Health Board, Cwm Taf University Health Board, Swansea Bay University Health Board and Cardiff and Vale University Health Board