University of Toronto, Malignant Hyperthermia Investigation Unit, Canisius Wilhelmina Hospital, Department of Clinical Sciences, Lund University, Department of Anaesthesiology, University Hospital Antwerp, Malignant Hyperthermia Investigation Unit, Canisius Wilhelmina Hospital, Department of Anaesthesia and Pain Management, The Royal Melbourne Hospital, The Royal Melbourne Hospital, Department of Anaesthesia and Pain Management, The Royal Melbourne Hospital, The Royal Melbourne Hospital, Department of Anesthesia, Malignant Hyperthermia Investigation Unit, University Health Network, University of Toronto, Department of Intensive and Perioperative Medicine, Skane University Hospital, Department of Biomedicine, Basel University Hospital, Basel University, Radboud University - Department of Neurology and King’s College London - Randall Division of Cell and Molecular Biophysics