University of Padua - Department of Industrial Engineering, University College London - Great Ormond Street Institute of Child Health, University of Padua - Department of Industrial Engineering, Veneto Institute of Molecular Medicine, University of Padua - Department of Industrial Engineering, University of Padua - Department of Industrial Engineering, ShanghaiTech University - Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University - Shanghai Institute for Advanced Immunochemical Studies (SIAIS), Telethon Institute of Genetics and Medicine (TIGEM), Armenise/Harvard Laboratory of Integrative Genomics, Next Generation Diagnostics, National Research Council (CNR) - Institute of Molecular Genetics, National Research Council (CNR) - Institute of Molecular Genetics, University of Padova - Department of Molecular Medicine, University of Padova - Department of Biology, Telethon Institute of Genetics and Medicine (TIGEM) - Armenise/Harvard Laboratory of Integrative Genomics, ShanghaiTech University - Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and University of Padua - Department of Industrial Engineering