University of Duisburg-Essen - Department of Endocrinology, Diabetes and Metabolism, Charité Research Organisation GmbH, Charité Research Organisation GmbH, University of Pennsylvania - Department of Obstetrics and Gynecology, University of Freiburg - Division of Endocrinology and Diabetology, University of Duisburg-Essen - Department of Endocrinology, Diabetes and Metabolism, University of Duisburg-Essen - Department of Endocrinology, Diabetes and Metabolism, Novartis Institutes for Biomedical Research, Cambridge - Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge - Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge - Translational Medicine, University of Duisburg-Essen - Department of Endocrinology, Diabetes and Metabolism and Novartis Institutes for Biomedical Research, Cambridge - Translational Medicine