Guangzhou Medical University, Guangzhou Medical University, Guangzhou Medical University, Guangzhou University of Chinese Medicine - Clinical Research and Data Center, State Key Lab of Respiratory Disease, Guangzhou Medical University, Guangzhou Medical University, Guangzhou Medical University, South China University of Technology - Guangzhou First People’s Hospital, Department of Pulmonary and Critical Care Medicine, South China University of Technology, Fifth People’s Hospital of Dongguan, Department of Pulmonary and Critical Care Medicine, outh China University of Technology, Clinical and Experimental Therapeutics, University of Georgia, Guangzhou Medical University, Guangzhou Medical University and Guangzhou Medical University - The State Key Lab of Respiratory Disease