Thushan I. de Silva

University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease

Medical School

University of Sheffield

Sheffield, S10 2RX

United Kingdom

Sheffield Teaching Hospitals NHS Foundation Trust - South Yorkshire Regional Department of Infection and Tropical Medicine

17 Mappin Street

Sheffield, S1 4DT

United Kingdom

SCHOLARLY PAPERS

9

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SSRN CITATIONS

4

CROSSREF CITATIONS

4

Scholarly Papers (9)

1.

Examining the Immunological Effects of COVID-19 Vaccination in Patients with Conditions Potentially Leading to Diminished Immune Response Capacity – The OCTAVE Trial

Number of pages: 25 Posted: 23 Aug 2021
University of Birmingham - NIHR Birmingham Biomedical Research Centre and Institute of Cancer and Genomic Sciences, University of Glasgow, Imperial College London, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Birmingham - Institute of Cancer and Genomic Sciences, Imperial College London, University of Oxford, NHS Foundation Trust - St. Georges University Hospitals, University Hospitals Birmingham NHS Foundation Trust, University of Leeds, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Glasgow - Institute of Infection, Immunity and Inflammation, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Imperial College London, Oxford University Hospitals NHS Foundation Trust, University of Glasgow and University of Glasgow
Downloads 4,485 (2,948)

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T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study

Number of pages: 55 Posted: 25 Mar 2021
University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Oxford - Sir William Dunn School of Pathology, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Sheffield Teaching Hospitals NHS Foundation Trust, University of Liverpool - HPRU in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Oxford University Hospitals NHS Foundation TrustUniversity of Oxford - Nuffield Department of Clinical Neurosciences, Public Health England Colindale, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute, University of Oxford - Peter Medawar Building for Pathogen Research, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Sheffield Teaching Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Department of Paediatrics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Oxford Vaccine Group, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, Public Health England Colindale, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Public Health England Colindale, University of Oxford - Sir William Dunn School of Pathology, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Birmingham - Institute of Cancer and Genomic Sciences, Newcastle upon Tyne Hospitals NHS Foundation Trust - Department of Infection and Tropical Medicine, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Wellcome Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease and Independent
Downloads 3,646 (4,058)
Citation 12

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T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study

Number of pages: 55 Posted: 13 Apr 2021
University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Oxford - Sir William Dunn School of Pathology, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Sheffield Teaching Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation TrustUniversity of Oxford - Nuffield Department of Clinical Neurosciences, Public Health England Colindale, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute, University of Oxford - Peter Medawar Building for Pathogen Research, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Sheffield Teaching Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Department of Paediatrics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Oxford Vaccine Group, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, Public Health England Colindale, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Public Health England Colindale, University of Oxford - Sir William Dunn School of Pathology, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Birmingham - Institute of Cancer and Genomic Sciences, Newcastle upon Tyne Hospitals NHS Foundation Trust - Department of Infection and Tropical Medicine, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Wellcome Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease and Independent
Downloads 486 (81,246)
Citation 12

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3.

Sustained T Cell Immunity, Protection and Boosting Using Extended Dosing Intervals of BNT162b2 mRNA Vaccine

Number of pages: 93 Posted: 21 Jul 2021
Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Oxford University Hospitals NHS Foundation TrustUniversity of Oxford - Nuffield Department of Clinical Neurosciences, University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Peter Medawar Building for Pathogen Research, Sheffield Teaching Hospitals NHS Foundation Trust, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Birmingham - Institute of Cancer and Genomic Science, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity and Cardiovascular Disease, Public Health England Colindale, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Wellcome Centre for Human Genetics, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Sheffield Teaching Hospitals NHS Foundation Trust, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford, University Hospitals Birmingham NHS Foundation Trust, Public Health England Colindale, Public Health England Colindale, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Peter Medawar Building for Pathogen Research, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, Oxford University Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Oxford Vaccine Group, University of Oxford - Centre for Vaccinology and Tropical Medicine, University of Oxford - Peter Medawar Building for Pathogen Research, Sheffield Teaching Hospitals NHS Foundation Trust, University of Oxford - Wellcome Trust Centre for Human Genetics, Oxford University Hospitals NHS Foundation Trust, University of Oxford - NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Public Health England Colindale, Newcastle upon Tyne Hospitals NHS Foundation Trust - Department of Infection and Tropical Medicine, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Wellcome Centre for Human Genetics, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research and Independent
Downloads 155 (260,385)
Citation 6

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4.

Co-Infections, Secondary Infections, and Antimicrobial Usage in Hospitalised Patients with COVID-19 from the ISARIC WHO CCP-UK Study: A Prospective, Multicentre Cohort Study

Number of pages: 22 Posted: 16 Feb 2021
University of Edinburgh - Centre for Inflammation Research, University of Edinburgh - Centre for Medical Informatics, University of Edinburgh - Centre for Medical Informatics, University of Liverpool - NIHR Health Protection Research Unit for Emerging and Zoonotic Infection, Queen Elizabeth University Hospital, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, University of Oxford - Nuffield Department of Medicine, University of Edinburgh - Centre for Medical Informatics, University of Edinburgh - Centre for Medical Informatics, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Edinburgh - Centre for Medical Informatics, University of Edinburgh - Centre for Medical Informatics, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, University of Oxford - ISARIC Global Support Centre, University of Liverpool - Liverpool Clinical Trials Centre, Public Health England - Emerging Infections and Zoonoses Unit, University of Nottingham - Division of Epidemiology and Public Health, Imperial College London - National Heart and Lung Institute, University of Edinburgh - Roslin Institute, University of Liverpool - Health Protection Research Unit in Emerging and Zoonotic Infections, University of Glasgow - MRC-University of Glasgow Centre for Virus Research and Independent
Downloads 84 (399,789)

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co-infection; secondary infection; bacteria; antimicrobial; SARS-CoV-2; COVID-19

5.

Poor Antibody Responses to SARS-CoV-2 Infection or Vaccination Are Associated With High Re-Infection Rates in Haemodialysis and Renal Transplant Patients

Number of pages: 20 Posted: 13 Oct 2021
University of Oxford - Transplantation Research and Immunology Group, University of Oxford, University of Oxford, University of Oxford - Peter Medawar Building for Pathogen Research, The Oxford Vaccine Group, University of Oxford - Oxford Vaccine Group, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford - Peter Medawar Building for Pathogen Research, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford, University of Oxford, University of Oxford, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford, University of Oxford - Nuffield Department of Surgical Sciences, University of Oxford, University of Oxford and University of Oxford - Nuffield Department of Clinical Medicine
Downloads 67 (453,163)

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SARS-CoV-2, Haemodialysis, transplant, end-stage renal disease, vaccine, re-infection

6.

The Alpha Variant B.1.1.7 Was Not Associated With Excess Healthcare Acquired COVID-19 Infection in a Multi-Centre UK Hospital Study

Number of pages: 29 Posted: 28 Jul 2021
University College London, University College London - Department of Infection, Inflammation and Immunity, University College London - Institute for Global Health, University College London - Department of Infection, Inflammation and Immunity, King's College London - Centre for Clinical Infection and Diagnostics Research, University of Portsmouth, Advanced Pathogen Diagnostics Unit, University College London Hospitals NHS Foundation Trust, King's College London - Centre for Clinical Infection and Diagnostics Research, University of Glasgow - Medical Research Council (MRC), University College London - Division of Infection and Immunity, Government of the United Kingdom - Portsmouth Hospitals NHS Trust, Bart's Health NHS Trust - Division of Infection, Bart's Health NHS Trust - Division of Infection, Bart's Health NHS Trust - Division of Infection, St. George’s University of London - Institute for Infection and Immunity, University of Glasgow - Medical Research Council (MRC), University of Sheffield - Sheffield Biomedical Research Centre, University Hospitals NHS Foundation Trust - Southampton Specialist Virology Center, North West London Pathology - Department of Infection and Immunity, University College London - Department of Infection, Inflammation and Immunity, NHS Foundation Trust - Department of Microbiology, Government of the United Kingdom - Royal Free London NHS Foundation Trust, NHS Foundation Trust - Southampton Specialist Virology Centre, Government of the United Kingdom - Sheffield Teaching Hospitals, University College London - Department of Genetics & Genomic Medicine, Independent, Independent, University College London - Institute for Global Health, Bart's Health NHS Trust - Division of Infection, University College London - Institute for Clinical Trials and Methodology, Health Data Research UK, Imperial College London - Section of Adult Infectious Disease, University of Glasgow - Medical Research Council (MRC), Government of the United Kingdom - Royal Free London NHS Foundation Trust, King's College London - Centre for Clinical Infection and Diagnostics Research, University College London Hospitals NHS Foundation Trust - Advanced Pathogen Diagnostics Unit, Government of the United Kingdom - Sheffield Teaching Hospitals, St. George’s University of London - Institute of Infection & Immunity, Imperial College Healthcare NHS Trust, University of Portsmouth, University of Southampton - University Hospital Southampton NHS Foundation Trust, University College London Hospitals NHS Foundation Trust - Department of Clinical Virology, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, King's College London - Centre for Clinical Infection & Diagnostics Research, MRC-University of Glasgow Centre for Virus Research, St. George’s University of London - Institute of Infection & Immunity and University College London - Department of Infection, Inflammation and Immunity
Downloads 39 (572,140)

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COVID-19; transmissibility; nosocomial outbreaks; lineage B.1.1.7; Alpha variant; SARS-CoV-2; variants of concern

7.

The Impact of Viral Mutations on Recognition by SARS-CoV-2 Specific T-Cells

Number of pages: 32 Posted: 12 May 2021
University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity and Cardiovascular Disease, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Sheffield Biomedical Research Centre, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford - Peter Medawar Building for Pathogen Research, Independent, University College London - Division of Infection and Immunity, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease and University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI)
Downloads 17 (717,613)
Citation 2

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8.

Pre-Existing Upregulation of Interferon Pathways in the Nasopharynx Impacts Viral Shedding Following Live Attenuated Influenza Vaccine Challenge in Children

Number of pages: 27 Posted: 29 Jul 2021
University of São Paulo - Department of Clinical and Toxicological Analyses, London School of Hygiene & Tropical Medicine - Medical Research Council Unit: The Gambia, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of São Paulo - Department of Clinical and Toxicological Analyses, University of São Paulo - Department of Clinical and Toxicological Analyses, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Medical Research Council Unit: The Gambia, Imperial College London - Department of Infectious Disease, Imperial College London - Department of Infectious Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Edinburgh - Queen’s Medical Research Institute, London School of Hygiene & Tropical Medicine - Medical Research Council Unit: The Gambia, Boston Children's Hospital - Division of Gastroenterology, Hepatology, and Nutrition, London School of Hygiene & Tropical Medicine - Medical Research Council Unit: The Gambia, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, University of São Paulo (USP) - Department of Clinical and Toxicological Analyses and University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease
Downloads 14 (742,879)

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LAIV, influenza, interferon stimulated genes, mucosal, transcriptome

9.

The Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonisation Densities Among Children Aged 24-59 Months in the Gambia - A Phase IV, Open Label, Randomised Controlled Trial

Number of pages: 27 Posted: 16 Apr 2021
University of Edinburgh - Queen’s Medical Research Institute, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, University of Edinburgh - Queen’s Medical Research Institute, University of Edinburgh - Queen’s Medical Research Institute, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, University of Edinburgh - Centre for Inflammation Research, London School of Hygiene & Tropical Medicine - Vaccines and Immunity Theme, University of Edinburgh - Queen’s Medical Research Institute and University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease
Downloads 10 (779,180)

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Live attenuated influenza vaccine, Pneumococcal colonisation, Viral-bacterial interactions