Inner Mongolia Medical University - Department of Basic Medicine, Hebei Medical University - Research Centre, Department of Orthopaedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center, Department of Orthopaedic Surgery and Biomedical Engineering, The University of Tennessee Health Science Center, Hebei Medical University - Research Centre, Hebei Medical University - Research Centre, Queen Elizabeth Hospital, Hong Kong, The University of Hong Kong - School of Chinese Medicine, Center of Integrative Research, The First Hospital of Qiqihar, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University Medical Center, University of Tennessee, Memphis - College of Nursing, Health Outcomes and Policy Research, Department of Clinical Pharmacy and Translational Science, University of Tennessee College of Pharmacy, Hebei Medical University - Research Centre, University of Tennessee, Memphis - Department of Orthopaedic Surgery and Biomedical Engineering and Peking University - Department of Gastrointestinal Surgery III