University of Cambridge - MRC Biostatistics Unit, MRC Biostatistics Unit, University of Cambridge, Postgraduate School of Public Health, Department of Biomedical Sciences for Health, University of Milan, MRC Biostatistics Unit, University of Cambridge, MRC Biostatistics Unit, University of Cambridge, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Welfare General Directorate, Regione Lombardia, Welfare General Directorate, Regione Lombardia, Government of the United Kingdom - Public Health England and Welfare General Directorate, Regione Lombardia