University of Dundee - Division of Population Health and Genomics, University of California, San Francisco (UCSF) - Department of Bioengineering and Therapeutic Sciences, University of Dundee - Division of Population Health and Genomics, Leiden University - Department of Cell and Chemical Biology, Genomic Medicine Institute, University of Dundee - Division of Population Health and Genomics, University of North Carolina (UNC) at Chapel Hill - Department of Pharmacology, University of North Carolina (UNC) at Chapel Hill - Eshelman School of Pharmacy, Kaiser Permanente Northern California Division of Research, Harvard University - Massachusetts General Hospital, VU University Amsterdam - Amsterdam Public Health Research Institute, VU University Amsterdam - Amsterdam Public Health Research Institute, Leiden University - Department of Cell and Chemical Biology, University of California, San Francisco (UCSF) - Department of Bioengineering and Therapeutic Sciences, Harvard University - Massachusetts General Hospital, Harvard University - Massachusetts General Hospital, University of California, San Francisco (UCSF) - Department of Epidemiology and Biostatistics, Genomic Medicine Institute, Geisinger, RIKEN Center for Integrative Medical Sciences, RIKEN Center for Integrative Medical Sciences, RIKEN Center for Integrative Medical Sciences, University of Dundee - Division of Population Health and Genomics, Harvard University - Massachusetts General Hospital, University of California, San Francisco (UCSF) - Department of Epidemiology and Biostatistics, Leiden University - Department of Cell and Chemical Biology, University of California, San Francisco (UCSF) - Department of Bioengineering and Therapeutic Sciences and University of Dundee - Division of Population Health and Genomics