University of Birmingham - NIHR Birmingham Biomedical Research Centre and Institute of Cancer and Genomic Sciences, University of Glasgow, Imperial College London, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, University of Birmingham, University of Oxford, University of Oxford, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Birmingham - Institute of Cancer and Genomic Sciences, Imperial College London, University of Oxford, NHS Foundation Trust - St. Georges University Hospitals, University Hospitals Birmingham NHS Foundation Trust, University of Leeds, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford - Peter Medawar Building for Pathogen Research, Mahidol University - Mahidol-Oxford Tropical Medicine Research Unit, University of Glasgow - Institute of Infection, Immunity and Inflammation, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Imperial College London, Oxford University Hospitals NHS Foundation Trust, University of Glasgow and University of Glasgow

Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Oxford University Hospitals NHS Foundation TrustUniversity of Oxford - Nuffield Department of Clinical Neurosciences, University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Peter Medawar Building for Pathogen Research, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Birmingham - Clinical Immunology Service, University of Birmingham - Institute of Cancer and Genomic Science, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, University of Oxford - Wellcome Trust Centre for Human Genetics, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity and Cardiovascular Disease, Public Health England Colindale, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Wellcome Centre for Human Genetics, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, Sheffield Teaching Hospitals NHS Foundation Trust, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford, University Hospitals Birmingham NHS Foundation Trust, Public Health England Colindale, Public Health England Colindale, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Peter Medawar Building for Pathogen Research, University of Liverpool - Institute of Infection, Veterinary and Ecological Sciences, Oxford University Hospitals NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Oxford Vaccine Group, University of Oxford - Oxford Vaccine Group, University of Oxford - Peter Medawar Building for Pathogen Research, Sheffield Teaching Hospitals NHS Foundation Trust, University of Oxford - Wellcome Trust Centre for Human Genetics, Oxford University Hospitals NHS Foundation Trust, University of Oxford - NIHR Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance, Public Health England Colindale, Newcastle upon Tyne Hospitals NHS Foundation Trust - Department of Infection and Tropical Medicine, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford - Peter Medawar Building for Pathogen Research, Mahidol University - Mahidol-Oxford Tropical Medicine Research Unit and Independent

University of Oxford - Transplantation Research and Immunology Group, University of Oxford, University of Oxford, University of Oxford - Peter Medawar Building for Pathogen Research, The Oxford Vaccine Group, University of Oxford - Oxford Vaccine Group, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford - Peter Medawar Building for Pathogen Research, Newcastle University - Translational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University - Translational and Clinical Research Institute, University of Birmingham - Institute of Cancer and Genomic Sciences, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Oxford, University of Oxford, University of Oxford, Mahidol University - Mahidol-Oxford Tropical Medicine Research Unit, University of Oxford, University of Oxford - Nuffield Department of Surgical Sciences, University of Oxford - Peter Medawar Building for Pathogen Research, University of Oxford - Wellcome Trust Centre for Human Genetics and University of Oxford - Nuffield Department of Clinical Medicine

The Christie NHS Foundation Trust, The University of Manchester, University of Manchester - Digital Experimental Cancer Medicine, affiliation not provided to SSRN, The University of Manchester, The University of Manchester, The University of Manchester, affiliation not provided to SSRN, ITG, Inc. - ITG London, affiliation not provided to SSRN, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, University of Dundee, affiliation not provided to SSRN, affiliation not provided to SSRN, Manchester Academic Health Sciences Centre - The Christie NHS Foundation Trust, Hospital General Universitario Gregorio Marañón, affiliation not provided to SSRN, University of Southampton - University Hospital Southampton NHS Foundation Trust, Fundeni Clinical Institute, Lahey Hospital and Medical Center - Division of Cardiovascular Medicine, affiliation not provided to SSRN, University Hospitals Plymouth NHS Trust, University of Manchester - Digital Experimental Cancer Medicine, University of Manchester - Digital Experimental Cancer Medicine, Lahey Hospital and Medical Center - Division of Cardiovascular Medicine, affiliation not provided to SSRN, The Christie NHS Foundation Trust, affiliation not provided to SSRN, affiliation not provided to SSRN, NHS Foundation Trust - Royal Marsden Hospital, Ninewells Hospital and Medical School, affiliation not provided to SSRN, University of Manchester - Research IT, affiliation not provided to SSRN, affiliation not provided to SSRN, University College London Hospital, Government of the United Kingdom - Oncology Department, Clatterbridge Cancer Centre, University College London - UCL Cancer Institute, Sheffield Teaching Hospitals NHS Foundation Trust, University of Southampton - Cancer Sciences Academic Unit, University of Lausanne - Lausanne University Hospital, Lahey Hospital and Medical Center, affiliation not provided to SSRN, Lahey Hospital and Medical Center - Department of Internal Medicine, affiliation not provided to SSRN, Centre Hospitalier Universitaire Vaudois (CHUV), Lahey Hospital and Medical Center, Bristol Haematology and Oncology Centre, affiliation not provided to SSRN, PSL Research University - Institut Curie, Royal Cornwall Hospital - Sunrise Centre, I.M. Sechenov First Moscow State Medical University, affiliation not provided to SSRN, affiliation not provided to SSRN, National Institute for Health Research (NIHR), Government of the United Kingdom - Oncology Department, University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Hospital Universitario La Paz - Department of Medical Oncology, The Christie NHS Foundation Trust, Government of the United Kingdom - Weston Park Cancer Centre, Government of the United Kingdom - Weston Park Cancer Centre, affiliation not provided to SSRN, affiliation not provided to SSRN, The Christie NHS Foundation Trust, Independent, The University of Manchester, The University of Manchester and The Christie NHS Foundation Trust

University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity and Cardiovascular Disease, University of Oxford - Wellcome Centre for Human Genetics, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield - Sheffield Biomedical Research Centre, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Liverpool - NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Mahidol University - Mahidol-Oxford Tropical Medicine Research Unit, Independent, University College London - Division of Infection and Immunity, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Oxford - Wellcome Centre for Human Genetics, University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI), University of Sheffield - Department of Infection, Immunity & Cardiovascular Disease and University of Oxford - Chinese Academy of Medical Science Oxford Institute (COI)